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Neural subspace reorganization reflects value-based decision making.

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    Brain decisions reorganize how options are represented in the lateral prefrontal cortex (LPFC). Chosen options are expanded and rotated into a subspace representing the correct action, improving action selection.

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    Area of Science:

    • Neuroscience
    • Cognitive Neuroscience
    • Decision Neuroscience

    Background:

    • Value-based decision-making involves comparing options and communicating choices to guide behavior.
    • Neural circuits for value-based decisions are known, but how decisions influence option representations is less understood.

    Purpose of the Study:

    • To investigate how decisions dynamically reorganize neural representations of options in the lateral prefrontal cortex (LPFC).
    • To understand the neural mechanisms by which decisions facilitate action selection.

    Main Methods:

    • Recorded neural activity from the LPFC in non-human primates (NHPs).
    • NHPs held two sequentially presented option-value pairs in working memory and chose the higher-value option.
    • Analyzed neural representations of chosen and unchosen options before and after decisions.

    Main Results:

    • Neural representations of chosen and unchosen options rotated into orthogonal subspaces post-decision.
    • The representation of the chosen option expanded and aligned with a consistent action subspace, irrespective of presentation order.
    • Before decisions, representations of sequentially presented options were maintained separately.

    Conclusions:

    • Decision-making dynamically reorganizes neural representations in LPFC.
    • This neural subspace reorganization facilitates selective and efficient readout of the chosen action.
    • LPFC plays a key role in transforming value-based decisions into actionable representations.