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Updated: Feb 14, 2026
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
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Donor Risk Factors Affecting Graft Survival in Pediatric Kidney Transplants: Protocol for a Systematic Review and
Cahyani Gita Ambarsari1,2,3, Jon Jin Kim4,5, Nur Hasnah Maamor6
1School of Medicine University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom, 44 (0)115 951 5151, 44 (0)115 951 3666.
JMIR Research Protocols
|February 12, 2026
Summary
This systematic review analyzes kidney donor risk factors affecting graft survival in pediatric kidney transplants (KTs). Understanding these factors is crucial for improving long-term outcomes in children needing transplants.
Area of Science:
- Pediatric Nephrology
- Transplant Surgery
- Biostatistics
Background:
- Pediatric end-stage kidney disease necessitates lifelong kidney transplants (KTs).
- Long-term graft survival hinges on donor and recipient factors.
- Updated analysis of donor risk factors is vital due to evolving transplant care and donor demographics.
Purpose of the Study:
- To systematically review and meta-analyze donor-related risk factors impacting graft survival in pediatric kidney transplantation.
- To exclude donation after circulatory death (DCD) transplants due to their lower incidence in pediatric cases.
Main Methods:
- Systematic review and meta-analysis of studies on donor risk factors in pediatric KTs.
- Inclusion of donor age, size, comorbidities, ethnicity, cause of death, and hospitalization duration.
- Literature search across PubMed, Scopus, Web of Science, Embase, and Cochrane databases.
- Study selection and quality assessment by two independent reviewers.
- Random-effects model for pooled estimates using Stata/BE software.
- PRISMA guidelines adherence for reporting.
Main Results:
- The review will synthesize evidence on kidney donor risk factors influencing pediatric KT graft survival.
- Anticipated completion of search and screening by June 2026.
- Data extraction, quality appraisal, and synthesis from July to October 2026.
- Publication of results expected in 2027.
Conclusions:
- This review offers a comprehensive synthesis of evidence on kidney donor risk factors in pediatric KTs.
- Findings will inform clinical decision-making and policy development.
- The study aims to improve outcomes for pediatric patients with end-stage kidney disease requiring transplants.
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