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Published on: July 15, 2015
Donor Risk Factors Affecting Graft Survival in Pediatric Kidney Transplants: Protocol for a Systematic Review and
Cahyani Gita Ambarsari1,2,3, Jon Jin Kim4,5, Nur Hasnah Maamor6
1School of Medicine University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom, 44 (0)115 951 5151, 44 (0)115 951 3666.
Insights
This systematic review analyzes kidney donor risk factors affecting graft survival in pediatric kidney transplants (KTs). Understanding these factors is crucial for improving long-term outcomes in children needing transplants.
Area of Science:
- Pediatric Nephrology
- Transplant Surgery
- Biostatistics
Background:
- Pediatric end-stage kidney disease necessitates lifelong kidney transplants (KTs).
- Long-term graft survival hinges on donor and recipient factors.
- Updated analysis of donor risk factors is vital due to evolving transplant care and donor demographics.
Purpose of the Study:
- To systematically review and meta-analyze donor-related risk factors impacting graft survival in pediatric kidney transplantation.
- To exclude donation after circulatory death (DCD) transplants due to their lower incidence in pediatric cases.
Main Methods:
- Systematic review and meta-analysis of studies on donor risk factors in pediatric KTs.
- Inclusion of donor age, size, comorbidities, ethnicity, cause of death, and hospitalization duration.
- Literature search across PubMed, Scopus, Web of Science, Embase, and Cochrane databases.
- Study selection and quality assessment by two independent reviewers.
- Random-effects model for pooled estimates using Stata/BE software.
- PRISMA guidelines adherence for reporting.
Main Results:
- The review will synthesize evidence on kidney donor risk factors influencing pediatric KT graft survival.
- Anticipated completion of search and screening by June 2026.
- Data extraction, quality appraisal, and synthesis from July to October 2026.
- Publication of results expected in 2027.
Conclusions:
- This review offers a comprehensive synthesis of evidence on kidney donor risk factors in pediatric KTs.
- Findings will inform clinical decision-making and policy development.
- The study aims to improve outcomes for pediatric patients with end-stage kidney disease requiring transplants.
Background:
Pediatric patients with end-stage kidney disease require kidney transplants (KTs) throughout their lifetime. Long-term graft survival is dependent on multiple factors, which are broadly categorized as donor- and recipient-related factors. Advances in transplant care and changes in donor population demographics necessitate an updated analysis on donor risk factors to guide clinical decision-making.
Objective:
In this systematic review and meta-analysis, we will focus on the impact of donor factors on graft survival in pediatric KT, excluding transplants from donation after circulatory death as the latter are less common in children.
Methods:
This review encompasses studies reporting donor-related risk factors for graft survival in pediatric KT, including age, size, comorbidities, and ethnicity for living and deceased donors, as well as the cause of death and length of hospitalization for deceased donors. The literature search will use the following databases: PubMed, Scopus, Web of Science, Embase, and Cochrane. Two independent reviewers will select studies and assess their quality. Pooled estimates of relevant factors will be computed via a random-effects model using the Stata/BE (version 19) software. Depending on data availability, subgroup analyses will be conducted based on donor type (living vs deceased). The reporting of findings will adhere to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.
Results:
The search and screening for the systematic literature review are anticipated to be finished in June 2026. Data extraction, quality appraisal, and subsequent data synthesis will begin in July 2026. The review is expected to be completed by October 2026, and the study results will be published in 2027.
Conclusions:
Our review will provide a comprehensive synthesis of the available evidence on kidney donor risk factors impacting graft survival in pediatric KT. The results of this review could provide valuable insights for clinical decisions, policy development, and ongoing efforts to improve outcomes for children with end-stage kidney disease requiring KT.
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