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Tuning tissue-resident memory T cells to fuel cancer immunotherapy
Yao Zhang1, Yi-Xuan Fang1, Yao Xiao1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430079, PR China.
Abstract:
As the threat of cancer to humanity continues to intensify, immunotherapy has emerged as a promising novel approach in cancer treatment. However, the efficacy of existing immunotherapy varies and needs to be improved urgently. Tissue-resident memory T (TRM) cells, a subset of T cells, have typical tissue-residency characteristics and formidable antitumor potential, which may be a latent enhancer for cancer immunotherapy. Besides, TRM cells are more readily modulated in the process of immunotherapy, compared to other T cell subsets present in the tumor microenvironment. This review summarizes the molecular phenotypes of TRM cells, introduces the relationship between TRM cells and cancer immunology, and proposes a range of potential immunotherapeutic strategies targeting TRM cells. Particularly, this review critically evaluates current clinical strategies and research aimed at modulating TRM cells. These insights are intended to provide new directions for tuning TRM for advancing cancer immunotherapy.
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