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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Efficient Sensing of a 4-Segmented Rift Valley Fever Virus Vaccine Candidate by Human Monocytes
Niranjana Nair1, Julia Friese1, Paul J Wichgers Schreur2
1Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover Foundation, Germany.
None:
The live-attenuated RVFV-4s vaccine against Rift Valley fever has demonstrated safety and efficacy across multiple animal models and in a phase 1 clinical trial. In this study, we examined its impact on innate immune responses and found that RVFV-4s enhances the expression of costimulatory molecules critical for T-cell activation, while triggering proinflammatory responses in primary human monocytes.
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