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Related Experiment Video

Updated: Feb 14, 2026

Sperm Collection and Computer-Assisted Sperm Analysis in the Teleost Model Japanese Medaka Oryzias latipes
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Sperm Testing in Assisted Reproductive Technology: Diagnosis and Outcome Prediction.

Kaixian Yan1, Ran Kong2, Defeng Liu3

  • 1Institute of Medical Technology, Peking University Health Science Center, Beijing, 100191, China. 2111110685@bjmu.edu.cn.

Reproductive Sciences (Thousand Oaks, Calif.)
|February 12, 2026
PubMed
Summary

Male infertility, often linked to declining sperm quality, requires advanced analysis. New technologies enhance sperm evaluation for better diagnosis and improved success rates in assisted reproductive technologies (ART).

Keywords:
Assisted reproductive technologyFunction testsGenetics analysisSemen routine testsSperm selection techniques

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Area of Science:

  • Reproductive biology
  • Andrology
  • Bioengineering

Background:

  • Infertility affects 1 in 6 couples globally, with male factor contributing significantly.
  • Declining sperm quality is a primary cause of male infertility, necessitating accurate diagnostic tools.
  • Conventional semen analysis is complemented by advanced tests like sperm DNA fragmentation and acrosome function assays.

Purpose of the Study:

  • To review advancements in sperm analysis technologies.
  • To highlight how these technologies improve understanding of sperm physiology and function.
  • To discuss the role of new technologies in enhancing sperm selection for assisted reproductive technologies (ART).

Main Methods:

  • Integration of advanced imaging (3D sperm imaging, high-precision microscopy) and genetic sequencing.
  • Detailed analysis of sperm movement, structure, function, and genetics.
  • Application of interdisciplinary approaches combining andrology, bioengineering, and computational biology.

Main Results:

  • Technological advancements provide deeper mechanistic insights into sperm physiology.
  • Precision screening enables enhanced sperm selection for ART.
  • Novel sperm analysis platforms are being developed for clinical application.

Conclusions:

  • New sperm analysis technologies offer significant improvements in diagnosing male infertility.
  • These advancements are crucial for optimizing sperm selection in ART, aiming to increase success rates.
  • The integration of diverse scientific fields is key to translating these innovations into clinical practice for male infertility management.