Related Experiment Video
Updated: Feb 14, 2026
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
15.6K
Platelet and Fibrinogen Dynamics After CAR-T Cell Therapy in Relapsed/Refractory B-Cell Lymphoma May Predict ICANS
Hazim Khatib1, Amit Parizat2, Jabour Halloun1
1Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
European Journal of Haematology
|February 13, 2026
Summary
Predicting immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T therapy is vital. Changes in platelet and fibrinogen levels may serve as early warning signs for ICANS development in lymphoma patients.
Area of Science:
- Hematology
- Oncology
- Immunotherapy
Background:
- CAR-T cell therapy shows efficacy in relapsed/refractory B-cell lymphoma.
- Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are significant complications of CAR-T therapy.
- Predicting and preventing ICANS is crucial for patient safety.
Purpose of the Study:
- To investigate the predictive value of coagulation parameter dynamics for ICANS development.
- To analyze the relationship between coagulation markers and ICANS in B-cell lymphoma patients undergoing CAR-T therapy.
Main Methods:
- Retrospective analysis of 265 B-cell lymphoma patients at two tertiary-care centers.
- Daily monitoring of platelet counts, fibrinogen, PT, PTT, INR, and D-dimer from pre-lymphodepletion to 2 weeks post-infusion.
- Comparison of coagulation parameters between patients with and without ICANS, including high-grade events.
Main Results:
- ICANS occurred in 34% of patients; high-grade ICANS in 13%.
- Patients with ICANS showed significantly lower median platelet and fibrinogen levels.
- A significant decrease in platelet counts and altered fibrinogen levels were observed preceding high-grade ICANS onset.
Conclusions:
- Platelet and fibrinogen dynamics may serve as early indicators for ICANS development in lymphoma patients.
- Monitoring coagulation parameters could aid in the prediction and management of ICANS after CAR-T therapy.
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