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Updated: Feb 14, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Published on: March 14, 2017

Hypoparathyroidism and Salivary Gland Dysfunction: A Single Center Case-Control Study.

Huseyin Yagci¹, Serife Mehlika Kuskonmaz¹, Gonul Koc¹

¹Department of Endocrinology and Metabolic Diseases, Ankara Training and Research Hospital, Ankara, Turkey.

|February 13, 2026

Summary

Hypoparathyroidism (hypoPT) is linked to lower salivary calcium and impaired salivary gland function, impacting oral health. This study highlights the oral health implications of hypoPT, emphasizing the need for further research.

Keywords:

hypoparathyroidism oral health salivary calcium salivary gland function xerostomia

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Area of Science:

Endocrinology
Oral Medicine
Radiology

Background:

Hypoparathyroidism (hypoPT) is an endocrine disorder characterized by insufficient parathyroid hormone (PTH) secretion, leading to hypocalcemia.
This condition can affect multiple organ systems and is potentially associated with salivary dysfunction and compromised oral health.

Purpose of the Study:

To investigate the impact of hypoparathyroidism on salivary calcium levels, salivary flow rate, and parotid gland structure.
To explore the implications of these changes for the oral health of patients with hypoparathyroidism.

Main Methods:

A case-control study was conducted with 86 participants (43 with hypoPT, 43 controls).
Salivary calcium, phosphorus, and magnesium levels were measured.
Salivary gland ultrasonography, sialometry, and oral health questionnaires were utilized.

Main Results:

Patients with hypoPT exhibited significantly lower salivary calcium levels compared to controls (p < 0.001).
Ultrasonography revealed a higher prevalence of parotid parenchymal heterogeneity in the hypoPT group (p = 0.025).
HypoPT patients reported worse oral health via questionnaire (p < 0.05) and had reduced salivary flow rates (p < 0.05).

Conclusions:

Hypoparathyroidism demonstrably affects salivary gland function and oral health.
The findings underscore the systemic impact of hypoPT, extending to oral health and salivary gland physiology.