Related Experiment Video
Updated: Feb 14, 2026
08:50
Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy
Published on: June 2, 2011
21.3K
Band Neutrophils Are Observed in Dogs Undergoing Multiagent Chemotherapy Including Vincristine
Caitlin N Eliason1,2, Steven J Pierce3, Alison Masyr1
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Animals : an Open Access Journal From MDPI
|February 13, 2026
Summary
Band neutrophils, or bandemia, are documented in dogs receiving chemotherapy. Smaller body surface area and certain chemotherapy drugs like vincristine and doxorubicin are linked to increased bandemia prevalence.
Area of Science:
- Veterinary Medicine
- Oncology
- Hematology
Background:
- Chemotherapy commonly induces neutropenia in dogs.
- Left shift, characterized by bandemia, has not been previously documented in dogs undergoing chemotherapy.
Purpose of the Study:
- To determine the prevalence of band neutrophil elevation in dogs receiving multiagent chemotherapy.
- To identify factors associated with bandemia development in these dogs.
Main Methods:
- Retrospective review of medical records from 2018-2022.
- Analysis of body surface area, white blood cell count, segmented and band neutrophil counts, and chemotherapy drugs administered.
- Statistical analysis using a generalized linear mixed model.
Main Results:
- Band neutrophils were present in 20.2% of nadir complete blood counts (CBCs).
- Increased band neutrophils (bandemia) occurred in 13.6% of CBCs.
- Smaller body surface area was associated with higher bandemia prevalence.
- Bandemia was more prevalent after vincristine or doxorubicin administration compared to cyclophosphamide.
Conclusions:
- Band neutrophils are present in dogs undergoing chemotherapy.
- Bandemia prevalence is negatively correlated with body surface area.
- Vincristine and doxorubicin administration are associated with a higher prevalence of bandemia.
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