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Updated: Feb 14, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
933
Second Primary Malignancies in Patients with Colorectal Cancer: The Frequency, Types, and Timeline
Zlata Lerner1,2, Sarah Weissmann3, Heba Abu-Kaf1,2
1The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel.
Journal of Clinical Medicine
|February 13, 2026
Summary
Colorectal cancer patients have a significantly increased risk of developing a second primary malignancy. Early screening for other cancers is crucial for these individuals, especially within the first three years post-diagnosis.
Area of Science:
- Oncology
- Cancer Epidemiology
Background:
- Colorectal cancer (CRC) is a global health concern, ranking as the third most common cancer worldwide.
- Understanding the occurrence of secondary primary malignancies (SPMs) in CRC patients is vital for comprehensive cancer care.
Purpose of the Study:
- To determine the frequency, types, and diagnostic timelines of SPMs in patients with a history of CRC.
- To identify risk factors associated with SPM development in CRC patients.
Main Methods:
- Retrospective cohort study of 65,774 patients diagnosed with CRC between 1999 and 2023.
- Data extracted from the Clalit database via the MDClone platform, including demographics and secondary cancer diagnoses.
- Analysis of cancer diagnosis timing relative to the primary CRC diagnosis.
Main Results:
- A total of 13,679 patients (21%) were diagnosed with a SPM.
- Female sex, smoking, and COPD were more common in patients with SPMs.
- Breast, prostate, and lung cancers were the most frequent SPMs, with distinct temporal patterns relative to CRC diagnosis.
Conclusions:
- Patients with CRC exhibit an elevated risk of developing a second primary cancer.
- Screening for other cancers should be recommended for CRC patients, with specific attention to Lynch syndrome in relevant cases.
- Consideration for colonoscopy screening in patients with prior breast or prostate cancer diagnoses is warranted.
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