Related Experiment Video
Updated: Jun 7, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Is Maternal Diabetes Mellitus Type 2 a Protective Factor for Atopic Dermatitis in Children? A Nationwide
Sarah Weissmann1, Nir Amitai1,2, Eliya Honig3
1From the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Background:
Maternal metabolic conditions may influence the risk of inflammatory diseases in offspring, yet the relationship between maternal type 2 diabetes mellitus (T2DM) and atopic dermatitis (AD) in children remains unclear.
Objective:
To evaluate the association between maternal T2DM and the development of AD in offspring.
Methods:
A retrospective cohort study of 314,224 mother-child pairs was conducted using electronic medical and birth records from Clalit Health Services in Israel (2010-2023). Maternal T2DM and child AD were identified by ICD-10 codes. Logistic regression was used to estimate adjusted odds ratios for AD, controlling for maternal age, socioeconomic status, gestational age, smoking, delivery type, ethnicity, and child sex.
Results:
Children born to mothers with T2DM had a lower crude prevalence of AD (23% vs 26%, P <0.001). Among mothers with T2DM, prior Glucagon-Like Peptide-1 (GLP-1) receptor agonist use was not associated with differences in offspring AD prevalence. After multivariable adjustment, maternal T2DM was not associated with AD (Adjusted Odds Ratio [aOR] = 0.95, 95% confidence interval: 0.87-1.03, P = 0.209). Higher socioeconomic status, parental smoking, male sex, and maternal allergic rhinitis were independent predictors of AD.
Conclusions:
Maternal T2DM was not found as a protective factor of AD in offspring. The observed protective trend may reflect confounding by sociodemographic or diagnostic factors. Prospective studies incorporating metabolic, immunological, and environmental data are warranted.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type II Diabetes I: Introduction
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology
Diabetes Mellitus: Introduction
