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Updated: Jun 4, 2026

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Cell-free DNA Levels in Cellulitis: A Cross-sectional Prospective Study.

Chaya Bracha Gordon1, Ayelet Ollech2, Gidon Test3

  • 1Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel.

Acta Dermato-Venereologica
|June 3, 2026
PubMed
Summary

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This summary is machine-generated.

Cell-free DNA (cfDNA) shows promise as a biomarker for cellulitis. Elevated cfDNA levels in patients correlated with disease severity and decreased with effective antibiotic treatment.

Area of Science:

  • Dermatology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Cellulitis lacks objective biomarkers for disease activity and treatment response.
  • Cell-free DNA (cfDNA) is a potential indicator of systemic inflammation.
  • Current management faces diagnostic ambiguity and treatment challenges.

Purpose of the Study:

  • To investigate cfDNA as a quantitative biomarker for cellulitis.
  • To assess the correlation between cfDNA levels and inflammatory markers.
  • To evaluate cfDNA's utility in monitoring therapeutic response and pain severity.

Main Methods:

  • Prospective cross-sectional study involving 36 cellulitis patients and 30 healthy controls.
  • Quantification of plasma cfDNA at multiple time points: admission, 72 hours post-antibiotics, discharge, and 3-week follow-up.

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  • Correlation analysis of cfDNA with C-reactive protein (CRP), white blood cell (WBC) counts, and pain scores.

    • Main Results:

    • Significantly elevated plasma cfDNA levels were observed in cellulitis patients at admission compared to controls.
    • cfDNA levels decreased rapidly following antibiotic therapy, correlating with reduced WBC counts.
    • Higher cfDNA levels were associated with increased patient-reported pain scores.

    Conclusions:

    • cfDNA shows potential as a diagnostic biomarker for cellulitis.
    • cfDNA can objectively monitor the efficacy of antibiotic treatment.
    • cfDNA may serve as an objective proxy for pain severity in cellulitis.