Related Experiment Video

Updated: Feb 14, 2026

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.5K

Serum Calprotectin in Hospitalized Patients with COVID-19 in Relation to High-Dimensional Serum Proteomic Patterns

Åsa Parke1,2, Benedikt Strunz2, Puran Chen2

  • 1Department of Infectious Diseases, Karolinska University Hospital, 141 57 Stockholm, Sweden.

International Journal of Molecular Sciences
|February 13, 2026
PubMed

Insights

Calprotectin is a potential biomarker for severe COVID-19 and sepsis. High calprotectin levels in patients with COVID-19 indicate neutrophil-driven inflammation and disease severity.

Area of Science:

  • Immunology
  • Proteomics
  • Infectious Diseases

Background:

  • Calprotectin is a potential biomarker for severe COVID-19 and sepsis.
  • The biological role of calprotectin in these conditions requires further investigation.

Purpose of the Study:

  • To investigate the association between serum calprotectin and the circulating proteome in COVID-19 patients.
  • To explore calprotectin's role as a biomarker in viral sepsis.

Main Methods:

  • Observational study of 160 hospitalized adult COVID-19 patients.
  • Serum calprotectin measured by turbidimetric assay.
  • Proteomics analyzed using the Olink Explore 1536 platform.

Main Results:

  • Higher median calprotectin levels in severe versus moderate COVID-19.
  • Calprotectin associated with a neutrophil-centered inflammatory proteomic signature.
  • Strongest correlation found between calprotectin and S100A12.

Conclusions:

  • Calprotectin is associated with COVID-19 disease severity.
  • High calprotectin reflects neutrophil-mediated hyperinflammation in viral sepsis.
  • Findings support calprotectin as a biomarker for neutrophil-driven inflammation.

Keywords:
COVID-19COVID-19 severityS10012Aproteomicssepsisserum-calprotectin

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.4K
Three-Dimensional, Serum-Free Culture System for Lacrimal Gland Stem Cells07:49

Three-Dimensional, Serum-Free Culture System for Lacrimal Gland Stem Cells

Published on: June 2, 2022

2.8K

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
460
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
896
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
645
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
233