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Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Multiple Regression01:25

Multiple Regression

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Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
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Correlation and Regression00:53

Correlation and Regression

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In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
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Regression Analysis01:11

Regression Analysis

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Regression analysis is a statistical tool that describes a mathematical relationship between a dependent variable and one or more independent variables.
In regression analysis, a regression equation is determined based on the line of best fit– a line that best fits the data points plotted in a graph. This line is also called the regression line. The algebraic equation for the regression line is called the regression equation. It is represented as:
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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Microsoft Excel: Regression Analysis01:18

Microsoft Excel: Regression Analysis

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Regression analysis in Microsoft Excel is a powerful statistical method for examining the relationship between a dependent variable and one or more independent variables. It's used extensively in fields such as economics, biology, and business to predict outcomes, understand relationships, and make data-driven decisions. The most common type is linear regression, which attempts to fit a straight line through the data points to model the relationship between variables.
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Related Experiment Video

Updated: Feb 14, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Twins With Pathogenic RNF113A Variant Presenting With Testicular Regression Syndrome.

Ortal Resnick1, Giovanna Beauchamp1

  • 1Division of Pediatric Endocrinology and Diabetes, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

JCEM Case Reports
|February 13, 2026
PubMed
Summary

Rare X-linked RNF113A disorders cause neurodevelopmental and endocrine issues. This study links a specific RNF113A variant to consistent symptoms in 46,XY twins, including testicular regression syndrome.

Area of Science:

  • Genetics
  • Endocrinology
  • Neurodevelopmental Disorders

Background:

  • RNF113A-related disorders are rare X-linked conditions.
  • Characterized by neurodevelopmental impairment, endocrine abnormalities, and gonadal dysgenesis.
Keywords:
disorders of sex developmenthypothyroidismtesticular regression syndrometrichothiodystrophyvanishing testeswhole exome sequencing

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  • Previously documented in very few individuals.