Research progress on long non‑coding RNAs in lung cancer (Review)

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Lung cancer presents significant challenges in early detection and advanced-stage treatment.
• Identifying reliable biomarkers and understanding molecular mechanisms are crucial for improving patient outcomes.
• Long non-coding RNAs (lncRNAs) are emerging as critical regulators in various cancer processes.

Purpose of the Study:

• To provide a comprehensive overview of the mechanistic roles of lncRNAs in lung cancer progression.
• To discuss the potential of lncRNAs as diagnostic and prognostic biomarkers.
• To review advancements in lncRNA detection technologies and their clinical translation.

Main Methods:

• Literature review synthesizing recent advances in lncRNA research related to lung cancer.
• Analysis of mechanistic roles of lncRNAs in tumor invasion, metastasis, proliferation, apoptosis, and angiogenesis.
• Discussion of lncRNA involvement in therapy response and chemoresistance.
• Evaluation of emerging lncRNA detection technologies and their clinical applicability.

Main Results:

• lncRNAs play significant roles in regulating key processes of lung cancer development and progression.
• Accumulating evidence supports the promise of lncRNAs as diagnostic and prognostic biomarkers.
• Various detection technologies are advancing, offering potential for clinical translation.
• Challenges and limitations in utilizing lncRNAs as biomarkers are identified.

Conclusions:

• lncRNAs represent a promising area for novel insights into lung cancer.
• Further research is needed to fully harness the potential of lncRNAs for clinical applications.
• Addressing current challenges is essential for the successful translation of lncRNA research into clinical practice.