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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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The Bidirectional Relationship Between Cognitive Function and Active Inflammatory Bowel Disease.

Bharati Kochar1,2,3, Adam S Faye4, Elizabeth Araka1

  • 1Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.

The American Journal of Gastroenterology
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Cognitive impairment is common in older adults with inflammatory bowel disease (IBD). Active IBD is linked to worsening cognitive function, particularly delayed recall, highlighting the need for effective IBD treatment in this population.

Keywords:
Crohn's diseaseagingdementiageriatricsulcerative colitis

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Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Gastroenterology

Background:

  • Cognitive impairment is a significant geriatric syndrome and a precursor to dementia.
  • Inflammatory bowel disease (IBD) affects a growing elderly population.
  • Understanding cognitive function in older adults with IBD is crucial for early detection and intervention.

Purpose of the Study:

  • To describe cognitive function in adults aged 60 and above diagnosed with IBD.
  • To investigate the association between IBD activity and cognitive function.
  • To identify potential early screening tools for cognitive decline in IBD patients.

Main Methods:

  • A cohort of 356 IBD patients aged ≥60 years was recruited from six US centers.
  • Demographics, IBD history, disease activity indices, and the Montreal Cognitive Assessment (MoCA) were collected.
  • Multivariate logistic regression models analyzed cognitive function changes and IBD activity over one year.

Main Results:

  • At baseline, 42% of participants screened positive for cognitive impairment, with deficits in delayed recall and visuospatial function being most common.
  • Within one year, 31% showed improved MoCA scores, while 19% experienced a decline.
  • Symptomatically active IBD at baseline significantly predicted worsening cognitive testing at follow-up (aOR: 3.01).

Conclusions:

  • Effective management of IBD in older adults is essential to mitigate cognitive decline.
  • Deficits in delayed recall, a MoCA sub-domain, are significantly associated with active IBD.
  • Delayed recall may serve as a valuable screening tool for cognitive impairment in elderly IBD patients.