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Societal Preferences, Values and Priorities for Genomic Testing for Atrial Fibrillation: Evidence from Two Discrete

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Genomic testing for atrial fibrillation is valued by patients and relatives, with cost being a key factor. Public funding could increase uptake, but support is needed for disadvantaged groups.

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Area of Science:

  • Cardiovascular Genetics
  • Health Economics
  • Bioethics

Background:

  • Atrial fibrillation (AF) is a common arrhythmia linked to stroke, heart failure, and mortality.
  • Genetic factors play a role in AF pathogenesis, offering potential for risk stratification and management.
  • Consumer preferences for genomic testing in AF are largely unexplored.

Purpose of the Study:

  • To investigate consumer preferences, values, and priorities for genomic testing in atrial fibrillation (AF).
  • To provide the first empirical evidence on the perceived value of AF genomic testing.

Main Methods:

  • Two discrete choice experiment surveys were conducted with the Australian public (n=503 symptomatic patients, n=506 at-risk relatives).
  • Participants evaluated hypothetical genomic testing scenarios based on five key attributes.
  • Panel error component mixed logit and latent class models were used for data analysis.

Main Results:

  • The highest valued benefits included personal cardiac monitoring and family health implications.
  • Testing cost was the primary determinant of preferences, with an estimated value of $2900 for symptomatic patients.
  • Predicted uptake was 82% if publicly funded, though lower socioeconomic groups showed less likelihood of uptake.

Conclusions:

  • Genomic testing for AF holds perceived value for both patients and at-risk relatives.
  • Addressing cost barriers and providing tailored education are crucial for equitable access.
  • Targeted support is essential to improve uptake among socioeconomically disadvantaged populations.