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Updated: Feb 15, 2026
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Diagnostic performance of colonoscopy after positive FIT in National Cancer Screening Program
Hyoung Il Choi1, Yunjin Joanne Yum, Hyewon Yang
1Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Medicine
|February 13, 2026
Summary
Men and standard fecal immunochemical test (FIT) cutoffs increase advanced neoplasia risk in colorectal cancer screening. Colonoscopy completion is crucial, especially for men with positive FIT results.
Area of Science:
- Gastroenterology
- Oncology
- Public Health
Background:
- The National Cancer Screening Program in Korea offers annual fecal immunochemical tests (FIT) to individuals aged 50 and above.
- Evaluating the effectiveness of FIT in detecting advanced neoplasia (AN) is crucial for optimizing screening strategies.
Purpose of the Study:
- To assess the diagnostic performance of colonoscopy following a positive FIT.
- To determine the prevalence ratio (PR) of advanced neoplasia (AN) in participants with positive FIT results.
- To identify factors associated with AN in this population.
Main Methods:
- Retrospective analysis of data from the National Cancer Screening Program (2007-2024).
- Inclusion of participants with positive FIT results, comparing AN prevalence based on sex, age, FIT cutoff, and anemia.
- Multivariable analysis to identify independent predictors of AN.
Main Results:
- A total of 2445 participants had positive FIT results; 50.6% underwent colonoscopy.
- The positive predictive value for AN was 15.4%.
- AN prevalence was significantly higher in males (PR=1.8) and with the standard FIT cutoff (PR=1.9). Male sex and standard FIT cutoff were independently associated with AN.
Conclusions:
- Advanced neoplasia is more common in males and when using the standard FIT cutoff in Korea's screening program.
- The low colonoscopy completion rate (50.6%) highlights the need for strategies to improve adherence.
- Targeted recommendations for colonoscopy completion are warranted for males and individuals with positive FIT results using the standard cutoff.
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