Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Alterations in Respiration II01:30

Alterations in Respiration II

1.9K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.9K
Altered States of Awareness01:06

Altered States of Awareness

1.2K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K
Quantifying Work02:30

Quantifying Work

24.6K
As a system undergoes a change, its internal energy can change, and energy can be transferred from the system to the surroundings, or from the surroundings to the system.
24.6K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenylalanyl-tRNA synthetase FARS-1/FARSA balances longevity and immunity by downregulating endogenous mitochondrial double-stranded RNAs.

Molecular cell·2026
Same author

Ribonuclease DIS3 delays aging and senescence by generating tRNA halves.

Nature communications·2026
Same author

A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer.

Cell reports methods·2026
Same author

Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.

Molecular cell·2026
Same author

Better than industry self-regulation: Compliance of mobile games with newly adopted and actively enforced loot box probability disclosure law in South Korea.

Acta psychologica·2025
Same author

Epigenetic synthetic lethality as a cancer therapeutic strategy: synergy of experimental and computational approaches.

Epigenomics·2025
Same journal

Protocol for inducing deep vein thrombosis in C57BL/6J mice using the inferior vena cava stenosis model.

STAR protocols·2026
Same journal

Overcoming the challenges of genome-editing essential genes.

STAR protocols·2026
Same journal

Protocol for longitudinal two-photon calcium imaging and holographic optogenetic manipulation to investigate memory in mice.

STAR protocols·2026
Same journal

Protocol for identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data.

STAR protocols·2026
Same journal

Protocol for in vitro phase separation of ARID3B proteins.

STAR protocols·2026
Same journal

Protocol for isolating human extracellular vesicles from nephrotic urine and enriching autoimmunoglobulin-triggered extracellular vesicles.

STAR protocols·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

429

Protocol for quantifying interaction patterns among genomic alterations in cancer.

Adrián Maqueda-Real1, Seokjin Ham1, Laia Ollé-Monràs2

  • 1Cancer Genomics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

STAR Protocols
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a new protocol to analyze complex genomic alteration interactions in cancer development. It helps researchers understand how mutations and copy number alterations (CNAs) work together in specific cancer contexts.

Keywords:
BioinformaticsCancerGenomicsSequencingSystems biology

More Related Videos

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K

Related Experiment Videos

Last Updated: Feb 15, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

429
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • Large-scale cancer datasets are crucial for understanding complex genomic alterations in tumorigenesis.
  • Existing methods may not fully capture the diverse interaction patterns between genomic alterations.

Purpose of the Study:

  • To present a protocol for quantifying diverse interaction patterns between genomic alterations.
  • To enable the analysis of context-specific genetic interactions in cancer.

Main Methods:

  • Preparation of a binarized alteration matrix from large-scale cancer datasets.
  • Analysis of mutation-copy number alteration (CNA) associations.
  • Examination of pairwise, high-order, and context-dependent associations.

Main Results:

  • The protocol effectively quantifies various genomic alteration interaction patterns.
  • It allows for the identification of context-specific genetic interactions relevant to tumorigenesis.

Conclusions:

  • This protocol provides a systematic approach to analyze complex genomic alteration associations.
  • It facilitates a deeper understanding of the genetic basis of cancer development.