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Lipid oxidation reprogramming in cancer-associated fibroblasts enhances CD8+ T cell cytotoxicity and therapeutic

Zikun Ma1, Yuzhao Wang2, Weikai Wang3

  • 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; State Key Laboratory of Neurology and Oncology Drug Development, Nanjing 210000, China.

Cancer Cell
|February 13, 2026
PubMed

Keywords:
CD8(+) T cell anti-tumor immunityPI3K/AKT/mTORPTENbladder cancercancer-associated fibroblastscell metabolismchemotherapyimmunotherapylipid metabolismtumor immune microenvironment

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