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Related Experiment Videos

Laser iridotomy and trabeculotomy in monkeys. A morphological study.

L Landecker, C Mortimer, P K Basu

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |January 1, 1978
    PubMed
    Summary

    This study evaluated argon laser procedures for glaucoma in monkeys. While laser iridotomy was successful, laser trabeculotomy showed limited effectiveness, suggesting it cannot replace current glaucoma surgeries.

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    Area of Science:

    • Ophthalmology
    • Veterinary Medicine
    • Biomedical Engineering

    Background:

    • Glaucoma management often involves surgical interventions.
    • Laser therapies are explored as alternatives to traditional surgical procedures.
    • The efficacy of specific laser systems for ophthalmic surgery requires investigation.

    Purpose of the Study:

    • To assess the effectiveness of the Britt Model 152 argon laser for performing laser iridotomy and laser trabeculotomy in non-human primates.
    • To evaluate the safety and outcomes of these laser procedures on ocular tissues.

    Main Methods:

    • Rhesus and Cynomologous monkeys underwent laser iridotomy and trabeculotomy using a repetitively pulsed argon laser (Britt Model 152).
    • Energy levels ranged from 2 to 6 joules.

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  • Histopathological analysis included light microscopy and scanning electron microscopy to assess tissue damage and procedural outcomes.

    • Main Results:

    • Laser iridotomy was successfully performed at the 3 and 9 o'clock positions and remained patent for at least two months with no observed lens damage.
    • Laser trabeculotomy resulted in anterior synechiae, corneal endothelial swelling, and trabecular coagulation.
    • Scanning electron microscopy revealed minimal perforation of the trabecular meshwork, even with high energy doses.

    Conclusions:

    • The Britt Model 152 argon laser is suitable for performing laser iridotomy in humans.
    • Laser trabeculotomy with this device demonstrated insufficient efficacy to replace current surgical glaucoma treatments.
    • Further research may be needed to optimize laser parameters for trabecular meshwork procedures.