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Related Concept Videos

Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Specific Heat01:16

Specific Heat

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The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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Related Experiment Video

Updated: Feb 15, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
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Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

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ASD: antigen-specific antibody database.

Arkadiusz Czerwiński1, Paweł Dudzic1, Konrad Wójtowicz1

  • 1R&D Department, NaturalAntibody, Szczecin, Poland.

Mabs
|February 14, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created the Antigen Specific Antibody Database (ASD) to address challenges in therapeutic antibody development. This comprehensive resource aids in predicting antibody-antigen interactions and binding affinity using aggregated data.

Keywords:
Antibody designbinding affinitybioinformaticscomputational immunologydatabasesdrug discovery

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Area of Science:

  • Biochemistry
  • Immunology
  • Bioinformatics

Background:

  • Computational modeling of therapeutic antibodies faces significant challenges, primarily due to limited and scarce data.
  • Predicting antibody-antigen interactions and binding affinity is crucial for antibody development but hindered by data scarcity.

Purpose of the Study:

  • To develop a comprehensive database of antibody-antigen interactions to support computational model development.
  • To aggregate and standardize antibody-antigen interaction data from diverse public sources.

Main Methods:

  • Compiled antibody-antigen interaction data from 15 distinct sources.
  • Standardized formatting and annotations for all aggregated data.
  • Integrated metadata including UniProt/PDB identifiers, target names, and experimental conditions.

Main Results:

  • Created the Antigen Specific Antibody Database (ASD) with 1,097,946 unique antibody-antigen interactions and 9575 unique antigens.
  • The ASD includes diverse affinity measures, qualitative binding data, and extensive metadata.
  • The database provides a foundation for developing and validating computational models for antibody research.

Conclusions:

  • The Antigen Specific Antibody Database (ASD) is a valuable, publicly available resource for antibody research.
  • ASD facilitates the development of computational models for predicting antibody-antigen binding affinity.
  • This integrated dataset promotes further data generation and advancements in therapeutic antibody development.