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Redox-active microneedles for disease management.

Brian Youden1, Andrew Carrier2, Naizhen Yu2

  • 1Department of Chemistry, Cape Breton University, Sydney, Nova Scotia B1P 6L2, Canada; Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 14, 2026
PubMed
Summary

Redox-active microneedles (RAMs) integrate redox biology and microneedle technology for targeted therapy. These wearable devices show promise for treating various conditions, advancing personalized medicine.

Keywords:
Drug deliveryInflammationNanomedicineReactive nitrogen speciesReactive oxygen speciesWearables

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Area of Science:

  • Biomedical Engineering
  • Redox Biology
  • Nanomedicine

Background:

  • Reactive oxygen and nitrogen species play crucial roles in cellular functions, disease, and aging.
  • Precise modulation of cellular redox states is a key medical strategy.
  • Microneedle technology offers advanced minimally invasive drug delivery.

Purpose of the Study:

  • To provide a comprehensive analysis of redox-active microneedles (RAMs).
  • To explore the potential applications of RAMs in treating diverse medical conditions.
  • To highlight the integration of redox biology with microneedle technology.

Main Methods:

  • Review of emerging literature on redox-active microneedles.
  • Analysis of patents, clinical trials, and research advancements.
  • Integration of redox biology principles with microneedle drug delivery systems.

Main Results:

  • Redox-active microneedles (RAMs) represent a novel class of wearable medical devices.
  • RAMs demonstrate broad therapeutic potential for conditions including infected wounds, cancer, psoriasis, diabetes, arthritis, hair loss, and skin aging.
  • Advancements in catalytic, photodynamic, and nanomedicine support RAM development.

Conclusions:

  • RAMs are poised to significantly impact personalized and precision medicine.
  • The combination of redox modulation and microneedle technology offers innovative treatment strategies.
  • Continued research and development are expected to expand the clinical applications of RAMs.