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Updated: Jan 15, 2026

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SERS-Integrated Microneedles: Bridging Nanoplasmonics and Microsampling for Advanced Bioanalysis.

Dongchang Yang1, Brian Youden1,2, Naizhen Yu1

  • 1Department of Chemistry, Cape Breton University, Sydney, Nova Scotia B1P 6L2, Canada.

ACS Sensors
|October 8, 2025
PubMed
Summary

Sensitive microneedles integrated with surface-enhanced Raman spectroscopy (SERS-MNs) offer a noninvasive method for real-time health monitoring. This technology enables convenient, self-administered biochemical analysis for diagnostics, agriculture, and food safety.

Keywords:
Raman spectroscopybiomarkersdiagnosisfood safetyin situ detectionmicroneedlesnanoparticlespharmaceuticalsplasmonicwearable devices

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Materials Science

Background:

  • Conventional biological sampling methods are invasive, costly, and inconvenient.
  • Sensitive analytical techniques are crucial for health monitoring, diagnostics, agriculture, and food safety.

Purpose of the Study:

  • To explore the emerging applications of surface-enhanced Raman spectroscopy-integrated microneedles (SERS-MNs).
  • To critically examine the requirements, working principles, challenges, and opportunities for SERS-MNs in various fields.

Main Methods:

  • Integration of microneedle (MN) technology with surface-enhanced Raman spectroscopy (SERS).
  • Development of portable, self-administered devices and wearable medical devices incorporating SERS-MNs.
  • Systematic examination of materials, structural design, and fabrication methods for SERS-MNs.

Main Results:

  • SERS-MNs provide a noninvasive, convenient, and highly sensitive approach for in vivo sampling of extracellular fluids.
  • The hybrid technique offers unprecedented user compliance and analytical sensitivity for biomonitoring.
  • SERS-MNs are suitable for point-of-care testing and real-time, long-term biochemical monitoring via wearable devices.

Conclusions:

  • SERS-MNs represent a versatile technology for clinical diagnostics, precision agriculture, and food safety.
  • Integration into wearable devices facilitates long-term, real-time health monitoring, empowering proactive health management.
  • Future opportunities lie in advancing SERS-MNs for widespread application in diverse monitoring scenarios.