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Updated: Feb 16, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

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Published on: September 16, 2022

Multifunctional biosensors redefining liquid biopsy: advancing simultaneous multianalyte detection.

Panagiota M Kalligosfyri¹, Antonella Miglione¹, Ada Raucci¹

¹Department of Pharmacy, University of Naples 'Federico II', Naples 80131, Italy.

Trends in Biotechnology

|February 14, 2026

Summary

Multifunctional biosensors advance liquid biopsy by detecting multiple biomarkers simultaneously. This improves disease diagnosis and monitoring, paving the way for precision medicine and early detection.

Keywords:

biosensor liquid biopsy multianalyte multifunctional

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Area of Science:

Biomedical Engineering
Molecular Diagnostics
Nanotechnology

Background:

Liquid biopsy enables noninvasive disease diagnosis by detecting circulating biomarkers.
Current single-analyte methods lack the sensitivity to capture complex diseases.
Multifunctional biosensors offer a new approach for comprehensive liquid biopsy analysis.

Purpose of the Study:

To review recent advancements in multifunctional biosensors for liquid biopsy.
To explore innovative detection strategies and integration technologies.
To discuss challenges and future directions for clinical translation.

Main Methods:

Review of diverse detection strategies: optical, electrochemical, plasmonic, CRISPR-based assays.
Exploration of hybrid platforms, surface engineering, and nanotechnology.
Discussion of integration with microfluidics, AI, and chemometric analysis.

Main Results:

Multifunctional biosensors enable simultaneous detection of multiple biomarkers.
Innovations enhance sensitivity, reduce interference, and improve scalability.
Integration with advanced technologies like AI and microfluidics is crucial.

Conclusions:

Multifunctional biosensors represent a paradigm shift in liquid biopsy.
These biosensors hold transformative potential for precision medicine and early disease detection.
Addressing challenges in clinical translation and standardization is key for widespread adoption.