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Pd-Catalyzed Three-Component Coupling of Aryl Bromides, Alkynes, and Anthranils To Access ortho Carbonyl N-Aryl
Wanting Chen1, Yanping Huo1, Qian Chen1
1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China.
Abstract:
A palladium-catalyzed three-component coupling of aryl bromides, alkynes, and anthranils has been developed for the direct and efficient synthesis of ortho carbonyl-substituted N-aryl indoles featuring a C-N chiral axis. Anthranil serves as an aryl nitrene precursor in this reaction, facilitating the expedient conversion of C,C-palladacycles into N-aryl indoles through sequential C-N bond formation. The in situ generated ortho carbonyl group within the product structure can be conveniently transformed into other functionalities, thereby enhancing the synthetic utility of this methodology.
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