Related Experiment Video
Updated: Feb 16, 2026

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton
Published on: May 7, 2016
Biomimetic Skeleton Conversion from Tiglianes into Three Euphorbia Diterpenoid Skeletons via Regioselective
Ming-Ju Wen1, Wei-Ye Wu1, Shu-Qi Wu1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, People's Republic of China.
Abstract:
Structurally complex Euphorbia diterpenoids represent a synthetic challenge. Here, we report a divergent strategy that biomimetically converts abundant tiglianes into three Euphorbia skeletons via regioselective cyclopropane ring-opening. The high utility of this approach was demonstrated in the semisynthesis of two rhamnofolane-type natural products, langduin A (4) and fischerianin A (5), via a single transformation. This work provides not only rapid access to these diverse diterpenoid frameworks but also chemical evidence of their potential biosynthetic relationship.
More Related Videos
07:40Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
Published on: February 11, 2022
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Related Concept Videos
Carbon Skeletons
Skeleton and Calcium Homeostasis
Overview of the Axial Skeleton
The axial skeleton of the...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Gene Conversion
Gene Conversion