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Related Concept Videos

Aging01:26

Aging

849
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
849
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
242
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

232
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
232
Mitochondria01:37

Mitochondria

20.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

717
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Updated: Feb 17, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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Renal aging: research models, interventions and development trends.

Yongpan An1, Ruixiao Li2, Rui Zhang3

  • 1Department of Urology, Xi'an People's Hospital (Xi'an Fourth Hospital), School of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi 710199, China; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, Shaanxi, China.

Drug Discovery Today
|February 15, 2026
PubMed
Summary
This summary is machine-generated.

Kidney aging leads to damage and disease, especially in the elderly. This review covers aging kidney changes, senescence models, and strategies to delay aging for better kidney health.

Keywords:
interventionsmodels of renal agingrenal aging

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Area of Science:

  • Nephrology
  • Gerontology
  • Molecular Biology

Background:

  • The aging kidney is susceptible to damage and is a risk factor for renal diseases.
  • Chronic kidney disease in the elderly is a growing global health concern.
  • Advances in understanding molecular and cellular mechanisms of renal aging are crucial.

Purpose of the Study:

  • To summarize pathological alterations in the aging kidney.
  • To explore disease models of renal senescence.
  • To review potential strategies for delaying kidney aging.

Main Methods:

  • Literature review of pathological changes in aging kidneys.
  • Systematic exploration of renal senescence disease models.
  • Analysis of potential interventions to delay kidney aging.

Main Results:

  • Detailed description of age-related pathological changes in kidney structure and function.
  • Overview of established and emerging models for studying kidney senescence.
  • Identification of therapeutic targets and strategies for mitigating kidney aging.

Conclusions:

  • Understanding renal aging mechanisms is key to preventing age-related kidney diseases.
  • Disease models provide insights into senescence and potential interventions.
  • Strategies to delay kidney aging offer a theoretical basis for future research and clinical practice.