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Renal aging: research models, interventions and development trends

Yongpan An1, Ruixiao Li2, Rui Zhang3

  • 1Department of Urology, Xi'an People's Hospital (Xi'an Fourth Hospital), School of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi 710199, China; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, Shaanxi, China.

Drug Discovery Today
|February 15, 2026
PubMed

Insights

Kidney aging leads to damage and disease, especially in the elderly. This review covers aging kidney changes, senescence models, and strategies to delay aging for better kidney health.

Area of Science:

  • Nephrology
  • Gerontology
  • Molecular Biology

Background:

  • The aging kidney is susceptible to damage and is a risk factor for renal diseases.
  • Chronic kidney disease in the elderly is a growing global health concern.
  • Advances in understanding molecular and cellular mechanisms of renal aging are crucial.

Purpose of the Study:

  • To summarize pathological alterations in the aging kidney.
  • To explore disease models of renal senescence.
  • To review potential strategies for delaying kidney aging.

Main Methods:

  • Literature review of pathological changes in aging kidneys.
  • Systematic exploration of renal senescence disease models.
  • Analysis of potential interventions to delay kidney aging.

Main Results:

  • Detailed description of age-related pathological changes in kidney structure and function.
  • Overview of established and emerging models for studying kidney senescence.
  • Identification of therapeutic targets and strategies for mitigating kidney aging.

Conclusions:

  • Understanding renal aging mechanisms is key to preventing age-related kidney diseases.
  • Disease models provide insights into senescence and potential interventions.
  • Strategies to delay kidney aging offer a theoretical basis for future research and clinical practice.
Keywords:
interventionsmodels of renal agingrenal aging

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