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Simultaneous Multi-Slice Acceleration for Free-Breathing Motion Corrected Late Gadolinium Enhancement Imaging.

Grzegorz Tomasz Kowalik1, Karl P Kunze1,2, Filippo Bosio1

  • 1Faculty of Life Sciences and Medicine, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

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|February 15, 2026
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Summary

Simultaneous multi-slice (SMS) accelerated free-breathing motion corrected and averaged late gadolinium enhancement MRI (FB PSIR-MoCo LGE) protocols cut scan times in half. This method maintained excellent agreement for myocardial scar assessment with minimal impact on image quality.

Keywords:
free‐breathinglate gadolinium enhancementmotion correctionsimultaneous multi‐slice

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Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Medical Technology

Background:

  • Late gadolinium enhancement (LGE) MRI is crucial for assessing myocardial scar.
  • Traditional LGE protocols can be time-consuming, limiting patient comfort and throughput.
  • Accelerated imaging techniques are needed to improve efficiency in cardiac MRI.

Purpose of the Study:

  • To develop and evaluate accelerated free-breathing motion corrected and averaged late gadolinium enhancement MRI (FB PSIR-MoCo LGE) protocols.
  • To assess the feasibility of using simultaneous multi-slice (SMS) imaging to reduce acquisition time.
  • To compare the diagnostic performance of SMS-accelerated LGE with a non-accelerated reference protocol.

Main Methods:

  • Implemented simultaneous multi-slice (SMS) bSSFP imaging with GC-LOLA correction (multiband factor of two) into a FB PSIR-MoCo LGE sequence.
  • Acquired two protocols in 26 patients: SMS-accelerated and non-SMS reference.
  • Assessed myocardial sharpness, contrast-to-noise ratios (CNRs), and scar volume; image quality was rated on a 4-point scale.

Main Results:

  • SMS acquisition reduced scan time by twofold (1.9 min vs. 3.7 min).
  • Image quality scores were slightly reduced but remained good to excellent (3.46 vs. 3.64).
  • Myocardial sharpness showed no significant difference; scar volume assessment showed excellent agreement (R²=0.996).

Conclusions:

  • The SMS FB PSIR-MoCo LGE protocol effectively reduces scan time by 50% with minimal impact on image quality and myocardial sharpness.
  • This accelerated protocol provides excellent agreement for myocardial scar assessment compared to the reference method.
  • SMS acceleration represents a promising advancement for efficient cardiac MRI.