Topical film-forming systems for antifungal delivery: emerging strategies and in-depth evaluation

Topical film-forming systems (FFSs) are a promising approach for antifungal therapy. After application, the solvent evaporates, leaving a thin polymeric film on the skin. This film acts as a drug reservoir, increasing residence time, improving patient comfort, and offering greater convenience compared with conventional creams and gels.

Examples of patented antifungal FFSs and available clinical trial data are included to illustrate translational potential. This review then outlines different types of FFSs such as sprays, solutions, gels, and emulgels. Evaluation methods, including mechanical strength, adhesion, substantivity, in vitro release testing (IVRT), in vitro permeation testing (IVPT) and antifungal activity, are also described. Searches of Google Scholar and PubMed were undertaken to gather the literature included in this review.

FFSs show superior benefits in treating superficial fungal infections by enhancing substantivity, providing sustained drug delivery, and improving adherence. Products such as single-application terbinafine films and novel nanocarrier - FFS hybrids demonstrate this potential. However, further standardized IVRT/IVPT clinical validation methods are needed to support wider adoption and ensure translation of laboratory findings into clinical outcomes.