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Updated: Feb 17, 2026
Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
Research progress on the spatiotemporal dynamics of therapy-induced senescence in remodeling the tumor
Qingqing Zhao1, Yunyan Yu2, Chaorui Pu3
1Department of General Surgery, The Second Affiliated Hospital of Zunyi Medical University, Guizhou, China.
Abstract:
This review systematically elaborates on the spatiotemporal dynamics and dual role of Therapy-Induced Senescence (TIS) in remodeling the Tumor Microenvironment (TME). The hallmark of TIS is the Senescence-Associated Secretory Phenotype (SASP), which drives multidimensional TME reprogramming through the secretion of various factors. These effects include the activation of Cancer-Associated Fibroblasts (CAFs), promotion of Vasculogenic Mimicry (VM), induction of metabolic reprogramming, and bidirectional regulation of the immune landscape. The article provides a focused analysis of the heterogeneous manifestations of this dual effect across different treatment stage and spatial locations, highlighting the definition of the threshold between its tumor-suppressive and tumor-promoting functions as a central current challenge. Finally, it explores future strategies involving multi-omics dynamic monitoring, artificial intelligence analysis, and spatiotemporally specific targeted interventions. In summary, this review aims to provide a theoretical foundation and translational directions for developing novel combination therapies targeting the senescent microenvironment by offering an in-depth analysis of the spatiotemporal dynamics of TIS.
Insights
Therapy-Induced Senescence (TIS) remodels the tumor microenvironment (TME) through its secretory phenotype. Understanding TIS
Area of Science:
- Oncology
- Cell Biology
- Cancer Research
Background:
- Therapy-Induced Senescence (TIS) is a cellular state triggered by cancer treatments.
- The Senescence-Associated Secretory Phenotype (SASP) is a key characteristic of TIS.
- TIS significantly influences the Tumor Microenvironment (TME).
Purpose of the Study:
- To systematically review the spatiotemporal dynamics of TIS in the TME.
- To elucidate the dual role of TIS in cancer progression and suppression.
- To explore novel therapeutic strategies targeting TIS.
Main Methods:
- Systematic literature review focusing on TIS and TME interactions.
- Analysis of SASP-mediated effects on TME components.
- Examination of TIS heterogeneity across treatment stages and locations.
Main Results:
- TIS, via SASP, drives multidimensional TME reprogramming.
- Key effects include Cancer-Associated Fibroblast (CAF) activation, Vasculogenic Mimicry (VM) promotion, metabolic reprogramming, and immune landscape modulation.
- The dual tumor-suppressive and tumor-promoting functions of TIS present a significant challenge.
Conclusions:
- TIS has a complex, context-dependent role in cancer therapy.
- Defining the threshold between TIS's beneficial and detrimental effects is crucial.
- Future strategies may involve multi-omics monitoring, AI, and targeted interventions for novel combination therapies.
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