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Updated: Aug 1, 2026

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
Published on: May 8, 2016
Isolated gastrointestinal Langerhans cell histiocytosis in a 16-month-old child: A case report
Al-Qasim Al-Bahlani1, Laraib Touseeq1, Mohammed Al-Masqari2
1Department of Child Health, Pediatric Gastroenterology and Hepatology Section Royal Hospital Muscat Sultanate of Oman.
Abstract:
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells, most often involving the skin or bone. Isolated gastrointestinal (GI) involvement is extremely uncommon in young children. We report a 16-month-old girl with a 1-month history of chronic vomiting, bloody diarrhea, and failure to thrive who was found to have GI-LCH without systemic involvement. She was started on standard LCH chemotherapy with a favorable clinical response. This case highlights the importance of considering LCH in infants/toddlers with unexplained GI symptoms and the utility of targeted molecular testing (e.g., BRAF mutation analysis) in guiding therapy.
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