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From ordering to interpretation: a comprehensive framework for laboratory test indications.

Jasmin Weninger1, Thomas Streichert2, Abdurrahman Coskun3

  • 1Department of Medicine, 9141 Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum , Bochum, Germany.

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Summary
This summary is machine-generated.

This study introduces a framework to standardize laboratory test indications, improving interpretation and stewardship. It links clinical intent to test results for better healthcare decisions.

Keywords:
clinical decision-makingdecision limitsdiagnostic stewardshiplaboratory utilization

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Area of Science:

  • Clinical laboratory science
  • Health informatics
  • Medical decision support

Background:

  • Clinical intent for laboratory testing (indication) is often unstructured, hindering interpretation and stewardship.
  • Lack of standardized indications limits auditability and effective utilization of laboratory resources.

Purpose of the Study:

  • To develop a comprehensive framework for standardizing laboratory test indications.
  • To link indications to context-dependent utilization and interpretation for improved clinical utility.

Main Methods:

  • A structured literature review and consensus-based process with a multidisciplinary expert panel.
  • Development of an indication taxonomy and attribute schema.
  • Assessment of structural coherence and feasibility through semantic distance analysis and use cases.

Main Results:

  • Defined 19 distinct indication types across five clinical clusters.
  • Developed structured attributes and examples for implementation.
  • Demonstrated that layered prototypes provide more informative organization than labels alone.

Conclusions:

  • The framework bridges the gap between test ordering and post-analytical interpretation.
  • Supports context-specific decision limits, reporting logic, and stewardship analytics.
  • Amenable to formalization as a machine-readable ontology for interoperable implementation.