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Updated: Feb 17, 2026

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Photocatalyzed Site-Selective Formal β-C(sp3)-H Sulfonylation of Ketones with Sulfinates
Jun Xu1, Jingyi Zhang1, Zhixiong Wang1
1College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.
Abstract:
Herein, we report a photocatalytic strategy for the site-selective formal β-C(sp3)-H sulfonylation of ketones. This method operates under mild conditions and exhibits broad functional group compatibility. Its utility is demonstrated through scalable synthesis and the late-stage functionalization of complex molecules. Mechanistic investigations suggest a reaction pathway involving a photoinduced hydrogen atom transfer (HAT) step, followed by copper-mediated reductive elimination. This protocol provides a direct route to valuable β-sulfonyl ketones from readily available starting materials and inexpensive reagents.
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