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Updated: Feb 18, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Aptamers-based drug: A new paradigm for precise treatment
Yuwen Zhou1, Shiqin Hong2, Xiaojie Xu3
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine/School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 561113, China; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
None:
Aptamer-drug conjugates (ApDCs) represent innovative therapeutics in recent drug development, emerging as a new modality for precision delivery. As a novel targeted cancer therapy strategy, ApDCs have significant advantages over antibody-drug conjugates (ADCs), including smaller molecular weight, higher chemical stability, lower immunogenicity, stronger tissue penetration, and easier engineering. Currently, ApDCs have established themselves as a highly competitive research landscape, garnering considerable attention from scientists worldwide. This review focuses on the latest progress in the ApDCs field from 2023 to 2025, with an emphasis on discussing solutions and emerging strategies to overcome the aforementioned challenges, aiming to provide references for promoting the further development and clinical application of ApDCs.
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