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Updated: Jun 24, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

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Published on: January 5, 2017

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi-Omics and

Tian Dai^1,2, Siyu Han^1,2, Xiaoping Hu²

¹School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of China.

Clinical and Translational Science

|June 23, 2026

Summary

Epoxide Hydrolase 2 (EPHX2) is a newly identified genetic factor in ulcerative colitis (UC). Its deficiency impairs intestinal epithelial cell healing, suggesting EPHX2 as a potential therapeutic target for UC.

Keywords:

EPHX2 genetics intestinal mucosal barrier ulcerative colitis

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Last Updated: Jun 24, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

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Published on: January 5, 2017

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Area of Science:

Genetics
Gastroenterology
Molecular Biology

Background:

Genetic factors are crucial in ulcerative colitis (UC) pathogenesis.
Identifying causal genes and their clinical relevance requires further investigation.

Purpose of the Study:

To identify and prioritize causal genes involved in UC pathogenesis using integrated genomic and transcriptomic data.
To investigate the role of Epoxide Hydrolase 2 (EPHX2) in intestinal epithelial cells (IECs) and its potential involvement in UC-related mucosal healing.

Main Methods:

Integrated genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data with UC-related differentially expressed genes (DEGs).
Mapped prioritized causal genes in single-cell datasets and validated EPHX2 expression in colitis mouse and in vitro models.
Utilized Gene Set Enrichment Analysis (GSEA) and functional assays to explore EPHX2's role in wound healing mechanisms.

Main Results:

Epoxide Hydrolase 2 (EPHX2) was identified as a causal gene expressed in epithelial subpopulations and significantly downregulated in colitis models.
EPHX2 deficiency was shown to impair mucosal repair capacity in functional studies.
GSEA indicated EPHX2's involvement in mucosal healing processes.

Conclusions:

EPHX2 deficiency may compromise intestinal epithelial cell-mediated mucosal healing in ulcerative colitis.
This study advances the understanding of genetic determinants in UC.
EPHX2 emerges as a potential therapeutic target for managing UC.