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Key Techniques in Microbiology01:19

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How to set up and manage a microbiome research facility.

Jannie G E Henderickx1, Wiep Klaas Smits1, Georg F Zeller1

  • 1Center for Microbiome Analyses and Therapeutics (CMAT), Leiden University Medical Center, Leiden, The Netherlands; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.

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Summary

Establishing dedicated microbiome research facilities is crucial for high-quality clinical studies. These centers centralize expertise, support innovation, and foster collaborations for microbiome analysis.

Keywords:
Clinical studiesExpertise centreHow toMicrobiomeResearch facility

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Area of Science:

  • Microbiome Research
  • Clinical Studies
  • Bioinformatics

Background:

  • Growing interest in microbiome research necessitates specialized support.
  • Microbiome analysis complexity requires domain expertise to avoid pitfalls.
  • Academic institutions need dedicated facilities for human microbiome research.

Purpose of the Study:

  • To provide an experience-based approach to establishing microbiome research facilities.
  • To outline essential aspects of a dedicated microbiome research facility.

Main Methods:

  • Review based on experiences establishing and running a facility at Leiden University Medical Center (LUMC) since 2017.
  • Analysis of advantages, structure, financial, and legal frameworks.
  • Discussion of key portfolio items for an expertise center.

Main Results:

  • Dedicated facilities support microbiome research in clinical studies.
  • Centralized activities, innovation, and validation of analytical methods are key benefits.
  • Facilities foster industrial collaborations and support funding applications.

Conclusions:

  • Dedicated microbiome research facilities are essential for high-quality research and education.
  • Centralized expertise facilitates design, execution, and interpretation of microbiome analyses.
  • These facilities are vital for advancing the field of gut microbiome research.