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Updated: Feb 18, 2026

Novel Triple-Loop Technique for Suturing TFCC Injuries without Transosseous Tunnel
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Tri-FR: A breakthrough?

Erwan Donal1, Julien Dreyfus2

  • 1University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, 35000 Rennes, France.

Archives of Cardiovascular Diseases
|February 16, 2026
PubMed
Summary
This summary is machine-generated.

Transcatheter edge-to-edge repair (T-TEER) significantly improves quality of life for elderly patients with severe tricuspid regurgitation (TR). This European trial offers key insights into T-TEER for symptomatic TR management.

Keywords:
Care pathwayEchocardiographyTranscatheter interventionTricuspid regurgitation

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Tricuspid regurgitation (TR) is prevalent, heterogeneous, and linked to poor outcomes.
  • TR is often undertreated due to limited surgical options and under-recognition.

Purpose of the Study:

  • To evaluate the efficacy of transcatheter edge-to-edge repair (T-TEER) plus optimized medical therapy in elderly, comorbid patients with severe symptomatic TR.
  • To provide the first European randomized controlled trial (RCT) evidence for T-TEER in this patient population.

Main Methods:

  • Investigator-initiated, multicenter randomized controlled study (Tri-FR trial).
  • Inclusion of elderly, comorbid patients with severe symptomatic TR (mean age 78, 64% women, 95% AF).
  • Rigorous imaging adjudication, real-world patient selection, and patient-centered endpoints.

Main Results:

  • T-TEER on top of optimized medical therapy improves quality of life and functional status.
  • The study highlights challenges in imaging, patient profiling, and procedural grading.

Conclusions:

  • Tri-FR trial provides benchmark evidence for T-TEER in severe symptomatic TR.
  • Findings support earlier referral and a balanced approach to repair versus replacement strategies.
  • Further data are needed for widespread adoption of transcatheter therapies.