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Spatial characterisation of TREM2 expression in actively demyelinating multiple sclerosis lesions supports its key

Yvonne A Aguirre Candia1, Ekaterina Aladyeva2, William J Boyden1

  • 1Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Acta Neuropathologica Communications
|February 17, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
DemyelinationMultiple sclerosisNeuroimmunologyPerilipin 2 (PLIN2)Spatial transcriptomicsTriggering receptor expressed on myeloid cells 2 (TREM2)

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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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