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Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review
Ying Tang1,2, Haodong Zhong1,2, Gaiying Li1,2
1Shanghai Key Laboratory of Magnetic Resonance, School of Physics, East China Normal University, Shanghai, China.
Human Brain Mapping
|February 17, 2026
Summary
Quantitative susceptibility mapping (QSM) uses voxel-wise analysis for detailed brain imaging, aiding in understanding neurological disorders and aging. This method offers insights into tissue properties and enhances research reproducibility.
Area of Science:
- Biomedical Imaging
- Neuroscience
- Medical Physics
Background:
- Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging technique.
- QSM quantifies magnetic susceptibility in biological tissues.
- It provides insights into iron deposition, hemorrhage, calcification, myelin, and oxygen extraction.
Purpose of the Study:
- To summarize voxel-wise analysis in QSM.
- To outline methodological considerations and clinical applications.
- To provide data processing recommendations for reproducibility.
Main Methods:
- Voxel-wise analysis of QSM data.
- Review of different analytical approaches (ROI-based, depth-wise, surface-based, network-based, voxel-wise).
- Focus on detailed examination of the entire brain.
Main Results:
- Voxel-wise analysis is increasingly prominent for detailed brain examination.
- This method is valuable for studying neurological pathologies and aging.
- It allows for comprehensive analysis without predefined regions.
Conclusions:
- Voxel-wise QSM analysis is crucial for investigating brain changes.
- Methodological considerations and clinical applications are summarized.
- Recommendations are provided to improve research transparency and reproducibility.
