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Related Concept Videos

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Related Experiment Video

Updated: Feb 18, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
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Altered Pain Perception and Modulation in Individuals With Post-COVID-Condition: Insights From Quantitative Sensory

Hannah Lange1, Julian Reichert2, Stephanie Vock1,2

  • 1Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.

European Journal of Pain (London, England)
|February 17, 2026
PubMed
Summary

Individuals with post-COVID condition (PCC) show altered pain processing, with lower pain thresholds and increased pain summation. These findings suggest central sensitization and the need for targeted pain management strategies for PCC patients.

Keywords:
ME/CFSconditioned pain modulationpain sensitivitypain thresholdpain tolerancepost‐COVID‐conditionquantitative sensory testingtemporal summation

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Area of Science:

  • Neuroscience
  • Pain Research
  • Immunology

Background:

  • Post-COVID condition (PCC) frequently involves chronic pain, but its mechanisms are unclear.
  • Investigating psychophysical pain indicators in PCC is crucial for understanding pain mechanisms.

Purpose of the Study:

  • To compare myofascial pain perception and modulation in individuals with PCC versus healthy controls (HC).
  • To correlate pain changes with clinical symptom severity in PCC.

Main Methods:

  • Quantitative sensory testing was used in 84 PCC patients and 50 HC.
  • Assessed pain detection/tolerance thresholds (PDT/PTT), spatial/temporal summation (SSP/TSP), and conditioned pain modulation (CPM).

Main Results:

  • PCC group had lower PDT and PTT, increased TSP, and decreased SSP.
  • CPM did not differ significantly, but HC showed more inhibitory responders.
  • Altered pain processing was more pronounced in PCC patients with chronic pain and severe symptoms.

Conclusions:

  • PCC is associated with altered myofascial pain perception, suggesting central sensitization.
  • Findings indicate nociplastic pain mechanisms in PCC, requiring further research for targeted therapies.