Related Experiment Video
Updated: Feb 18, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic esophagitis in children: Clinical perspectives and evolving therapeutic strategies
Arghya Samanta1, Vishrut Singh2, Bipresh Chakraborty3
1Department of Pediatric Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata 700020, West Bengal, India. arghyasamanta2905@gmail.com.
Abstract:
Eosinophilic esophagitis (EoE) is a chronic, antigen-mediated inflammatory condition of the esophagus, characterized by signs of esophageal dysfunction and characteristic endoscopic and histological features. Currently, EoE has developed from a rare disease entity to a prevalent condition with a rising incidence and prevalence in children. Over the past few decades, a deeper understanding of the underlying pathophysiologic mechanisms of EoE has led to better diagnostic and therapeutic strategies. Pediatric patients with EoE face a diagnostic dilemma due to a wide spectrum in symptomatology as well as limited pharmacological armamentarium. Emerging literature is showing promise, especially with dupilumab, a newer biologic with disease modifying potential. In this review we discussed new diagnostic and treatment strategies and future directions of monitoring EoE in children.
Related Concept Videos
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

