Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure-Activity Relationships and Drug Design

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to "Multienzyme Active Nanozyme for Efficient Sepsis Therapy through Modulating Immune and Inflammation Inhibition".

ACS applied materials & interfaces·2026

Same author

Atomically Modulated WSe<sub>2</sub> Clusters with Enhanced Biocatalytic Activity for Acute Liver Injury Management.

ACS applied materials & interfaces·2026

Same author

Correction to "Multifunctional Hydrogels Loaded with Mn Single-Atom Nanozymes: Advancing Endometrial Repair".

ACS applied materials & interfaces·2026

Same author

Atomic-scale RuS<sub>2-<i>x</i></sub> clusters with rich defects for efficient electron trapping of bacterial respiratory chains.

Materials horizons·2026

Same author

Light up the 'Dark'─Near-Infrared II.

Accounts of chemical research·2026

Same author

Opening Extra Transport Channels by Atomically Precise Doping in Gold Nanoclusters with Electronic Structure Modulation.

The journal of physical chemistry. A·2026

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Design and Biomedical Applications of Bioactive Clusters.

Di Liu¹, Hao Wang¹, Xiao-Dong Zhang¹

¹Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|February 17, 2026

Summary

Bioactive clusters show tunable properties for biomedical uses like therapy and imaging. This review covers their design, diverse activities, and future potential in medicine.

Keywords:

bioactive clusters biocatalysis bioimaging oxidative stress and inflammation‐related disease tumor

More Related Videos

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Related Experiment Videos

Last Updated: Feb 19, 2026

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Bioactive clusters possess tunable structures and diverse biological activities.
These properties enable applications in disease therapy, bioimaging, and drug delivery.

Purpose of the Study:

To review the classification and bioactivities of bioactive clusters.
To elucidate rational design strategies for bioactive clusters.
To highlight their therapeutic and imaging applications.

Main Methods:

Literature review of bioactive clusters.
Analysis of their biocatalytic, optical, photothermal, and photodynamic effects.
Summary of therapeutic applications (tumors, oxidative stress, inflammation) and imaging modalities.

Main Results:

Bioactive clusters demonstrate significant potential in treating tumors and inflammation-related diseases.
Their biocatalysis and anti-inflammatory activities are key therapeutic mechanisms.
Advanced imaging capabilities include noninvasive imaging and 3D visualization, supporting integrated therapy.

Conclusions:

Bioactive clusters offer versatile platforms for advanced biomedical applications.
Rational design and activity programming are crucial for optimizing their use.
Future development, including AI-driven design and biosafety evaluation, will accelerate clinical translation.