Total Synthesis of Indoline-Based Natural Products and Their Analogues
Yunfeng Zhang1, Ningtao He1, Yu Tang1,2,3
1Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
The Journal of Organic Chemistry
|February 17, 2026
Abstract
None:
We report a concise total synthesis strategy for accessing four fused tricyclic indoline-based natural products and their derivatives. The synthesis employs phosphine-catalyzed allylic alkylation as the key step to construct common precursors, which are subsequently functionalized to form the fused ring systems. Notably, the synthetic route is readily scalable, enabling the efficient preparation of a library of indoline-based alkaloids.
