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Pulmonary Function Testing Using Tidal Breath Flow-Volume Loops in Healthy Children 1-24 Months of Age in Semi-Rural

Charl Verwey1, Srijana Dongol2, Renu Shahi2

  • 1Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa.

Pediatric Pulmonology
|February 18, 2026
PubMed

Insights

Establishing a pediatric pulmonary function lab in Nepal is feasible. High-quality tidal breath flow-volume loop (TBFVL) testing was achieved, providing crucial data on lung function in Nepali children.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Global Health

Background:

  • Early-life respiratory insults impact lifelong lung function.
  • Nepal faces high burdens of lower respiratory infections and pollution.
  • Assessing these factors requires robust infant lung function data.

Purpose of the Study:

  • To determine the feasibility of establishing a pulmonary function laboratory in Nepal.
  • To conduct tidal breath flow-volume loop (TBFVL) testing in infants and children.
  • To enable assessment of early-life factors on lung development in Nepal.

Main Methods:

  • A pulmonary function laboratory was established in Dhulikhel, Nepal.
  • TBFVL testing was performed on healthy children aged 1-24 months.
  • Results were interpreted by trained local staff with international expert oversight.

Main Results:

  • 80 out of 86 (93%) children completed successful TBFVL tests.
  • Coefficient of variation (CoV) for TBFVL indices ranged from 4.7% to 19.5%.
  • Good agreement was found between local and international expert interpretations.

Conclusions:

  • Establishing a pediatric pulmonary function laboratory in Nepal is feasible.
  • High-quality TBFVL measurements meeting international standards were achieved.
  • This study contributes essential data on normal pulmonary function in Nepali children.
Abstract

Keywords:
childrendeterminants of lung healthpulmonary function testingtidal breath flow‐volume loops

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