Related Experiment Video
Updated: Feb 19, 2026
Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
The Effect of Cranberry Consumption on C-Reactive Protein and Interleukin-6: A Systematic Review and Meta-Analysis of
Mohammad Reza Amini1, Mahsa Elahikhah2, Sajjad Etesamnia3
1Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran.
Abstract:
Previous clinical trials examining the effects of cranberry on inflammatory markers have yielded inconsistent results. This study specifically aimed to assess the influence of cranberry consumption on C-reactive protein (CRP) and Interleukin-6 in randomized controlled trials (RCTs). A thorough systematic review was conducted by searching ISI Web of Science, Cochrane Library, PubMed, Scopus, and Google Scholar up to December 21, 2024, with no language restrictions applied, by two independent authors. The results were synthesized using the DerSimonian and Laird random-effects model. From an initial pool of 1882 articles, 10 were selected for the systematic review and meta-analysis. The findings indicated that cranberry did not significantly influence CRP (weighted mean differences (WMD): 0.01 mg/L; 95% CI: -0.38 to 0.40, p = 0.95; I 2: 80.8%) or Interleukin-6 (WMD: -0.26 pg/mL; 95% CI: -1.78 to 1.27, p = 0.74; I 2: 86.1%). However, it was observed that cranberry consumption was associated with a significant rise in CRP levels in obese individuals or in studies focused solely on women. Furthermore, research showed that the active ingredient in cranberry, when administered in powder form, could lead to a considerable increase in interleukin-6 levels. This review and meta-analysis suggest that cranberry supplementation did not affect CRP or Interleukin-6 levels. To further assess and validate these results, more long-term and well-designed RCTs are needed.
More Related Videos
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...