Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

20.8K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.8K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

2.2K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
2.2K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

1.7K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
1.7K
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

17.8K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
17.8K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

4.8K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Construction of an Infection-Inflammation Microenvironment-Regulating Nano-antimicrobial Agent and Application in the Treatment of Burn Wounds Complicated with Multidrug-Resistant Staphylococcus aureus Infection.

ACS applied materials & interfaces·2026
Same author

Exercise Intensity and Circulating Exerkine Responses: A Narrative Review of Selected Molecules.

Biomolecules·2026
Same author

Effectiveness and cost-effectiveness of pembrolizumab in persistent, recurrent, or metastatic cervical cancer with PD-L1 CPS 1-10: secondary analysis of KEYNOTE-826 using innovative KMSubtraction.

Expert review of pharmacoeconomics & outcomes research·2026
Same author

Systematic identification of human anti-mouse antibody interference causing falsely elevated B-type natriuretic peptide: A case study.

Annals of clinical biochemistry·2026
Same author

Association of haematological cancer drugs recommendation levels in Chinese Society of Clinical Oncology guideline with different approval approaches: a cross-sectional study.

BMJ public health·2026
Same author

Troponin I interference in an 18-year-old patient with bradycardia: a case study.

Clinical biochemistry·2026

Related Experiment Video

Updated: Feb 19, 2026

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K

Mitochondria: the central hub linking exercise to enhanced cardiac function.

Jiaqin Cai1, Tutu Wang1, Shunchang Li1

  • 1Sports Medicine Key Laboratory of Sichuan Province, Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.

Frontiers in Physiology
|February 18, 2026
PubMed
Summary

Regular physical exercise protects the heart by improving mitochondrial function, counteracting damage from a sedentary lifestyle. This review explores how exercise enhances cardiac health through key mitochondrial pathways.

Keywords:
exerciseheartinflammatory responsemitochondriaoxidative stress

More Related Videos

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.3K
Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes
08:04

Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes

Published on: August 16, 2021

3.0K

Related Experiment Videos

Last Updated: Feb 19, 2026

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K
Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.3K
Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes
08:04

Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes

Published on: August 16, 2021

3.0K

Area of Science:

  • Cardiovascular Physiology
  • Mitochondrial Biology
  • Exercise Science

Background:

  • Sedentary lifestyles are a significant risk factor for cardiovascular disease, contributing to endothelial dysfunction, inflammation, and mitochondrial damage in heart cells.
  • Cardiovascular disease remains a leading cause of global mortality, highlighting the need for effective prevention and intervention strategies.
  • Mitochondrial dysfunction in cardiomyocytes is a key pathological feature linked to sedentary behavior and impaired cardiac health.

Purpose of the Study:

  • To review the current evidence on how regular physical exercise modulates mitochondrial function in the heart.
  • To elucidate the specific mitochondrial mechanisms, including respiration, dynamics, and calcium handling, that mediate exercise-induced cardioprotection.
  • To provide a mechanistic perspective on how lifestyle choices, specifically exercise versus sedentary behavior, impact cardiac health via mitochondrial regulation.

Main Methods:

  • Comprehensive literature review of studies investigating exercise, sedentary behavior, and cardiac mitochondrial function.
  • Analysis of recent research on mitochondrial respiration, dynamics, calcium homeostasis, inflammation, and oxidative stress in the context of exercise.
  • Synthesis of evidence linking lifestyle-induced mitochondrial alterations to cardiovascular outcomes.

Main Results:

  • Exercise effectively mitigates sedentary-related cardiac damage and improves cardiac function by targeting mitochondria.
  • Key exercise-induced improvements in mitochondrial function involve enhanced respiration, balanced dynamics, regulated calcium signaling, and reduced oxidative stress.
  • Mitochondria are central to mediating the cardioprotective effects of physical activity, acting as key targets for exercise interventions.

Conclusions:

  • Exercise-induced enhancements in mitochondrial function are a core mechanism underlying its cardioprotective benefits.
  • Understanding these mitochondrial pathways provides critical insights into how lifestyle behaviors shape cardiac health.
  • Targeting mitochondrial function represents a promising strategy for preventing and managing cardiovascular disease.