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Published on: February 23, 2014
Interventions to improve pneumococcal vaccination coverage: A systematic review and meta-analysis
Bogdan Cireașă1, Géraldine Leguelinel-Blache1,2,3, Bob-Valéry Occéan4
1Department of Pharmacy, Nimes University Hospital, University of Montpellier, Nîmes 30900, France.
Low pneumococcal vaccination coverage is a concern. Interventions like education and reminders can increase coverage, with pharmacist-led strategies showing promise. Further research can guide targeted strategies to improve public health.
Area of Science:
- Public Health
- Infectious Disease Prevention
- Vaccinology
Background:
- Streptococcus pneumoniae causes severe infections like meningitis.
- Pneumococcal vaccination is optimal for prevention but coverage is low.
- This meta-analysis evaluates interventions to boost vaccination rates.
Purpose of the Study:
- To assess the impact of interventions on pneumococcal vaccination coverage.
- To identify factors influencing vaccination uptake.
- To guide the development of effective vaccination strategies.
Main Methods:
- Meta-analysis and mixed-effects meta-regression of studies from 2013-2023.
- Included randomized controlled trials (RCTs) and comparative non-RCTs.
- Subgroup analysis by study design, intervention type, facilitator, and population.
Main Results:
- 16 articles were included; 10 RCTs and 6 non-RCTs.
- Pooled relative risk (RR) for interventions was 1.06 (p=0.04).
- RCTs showed lower effect sizes than non-RCTs; pharmacist-led interventions were nearly significant (p=0.07).
Conclusions:
- Interventions can influence pneumococcal vaccination coverage.
- Direct interventions like education and reminders are common.
- Findings guide targeted strategies to improve vaccination rates.
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