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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Paediatric Crohn's Disease Management: A Mini Review Exploring Conventional and Innovative Therapies With Promising

Linah Wetthasinghe1, Hien Fuh Ng1, Kee Seang Chew2

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Pediatric Crohn's disease (pCD) is rising globally, impacting children's growth and quality of life. Current treatments have limits, prompting research into novel microbiome and immune therapies for better pediatric Crohn's disease management.

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fecal microbiota transplanthelminthic therapynutritional therapypediatric Crohn's diseasepharmacological intervention

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Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Microbiome Science

Background:

  • Pediatric Crohn's disease (pCD) incidence is increasing worldwide, including in Asia.
  • pCD significantly affects children's quality of life through gastrointestinal issues, growth failure, and malnutrition.
  • Understanding pCD epidemiology and pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To review current knowledge on pediatric Crohn's disease epidemiology and pathogenesis.
  • To discuss conventional and emerging management strategies for pCD.
  • To highlight the need for further research into novel therapies for pCD.

Main Methods:

  • Literature review of pediatric Crohn's disease epidemiology, pathogenesis, and treatment.
  • Analysis of conventional therapies (aminosalicylates, corticosteroids, biologics, nutrition).
  • Exploration of emerging treatments (helminthic therapy, FMT, synthetic biotics).

Main Results:

  • Dysbiosis, environmental factors, and immune dysregulation are key in pCD pathogenesis.
  • Conventional treatments have limitations in efficacy, tolerability, and long-term safety.
  • Emerging therapies targeting the microbiome and immune system show promise but require more pediatric data.

Conclusions:

  • Integrated approaches combining established and novel strategies are needed for personalized pCD care.
  • Further research is essential to optimize novel therapeutic protocols and assess long-term outcomes in pediatric populations.
  • Innovative treatments offer potential for more effective management of pediatric Crohn's disease.