Immunohistological parathormone production changes and angiogenesis in normal and adenomatous human parathyroid
Teruyuki Sato1, Yutaka Tateda2, Kazue Ise3
1Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. teruyukisato@tohoku-mpu.ac.jp.
Introduction:
Parathyroid tumor function is not always positively correlated with tumor size, complicating the disease picture. Here, we compared parathormone (PTH) and vascular endothelial growth factor (VEGF)-A expression intensities in normal and adenomatous parathyroid glands, as well as the number of vessels, as determined by CD31 expression.
Methods:
Eight adenomatous and six normal samples were compared for the expression intensities of PTH and VEGF-A, expression granule area of VEGF-A per unit area (/900 μm2), and number of blood vessels. We then examined relationships between the expression intensities of PTH and VEGF-A and the number of blood vessels.
Results:
The mean (SD) expression intensities of PTH and VEGF-A were 179.7 (27.5) and 100.6 (13.9) bits, respectively, in the normal group-significantly higher than the 99.0 (37.6) and 73.5 (19.5) bits in the adenoma group (p<0.01). The mean (SD) expression granule area of VEGF-A was 86.0 (41.2) μm2/900 μm2 in the normal group-significantly higher than the 13.7 (11.5) μm2 in the adenoma group (p<0.001). The mean (SD) number of blood vessels by CD31 expression was 26.0 (6.9) in the normal group-significantly higher than the 13.9 (8.7) in the adenoma group (p<0.05). The mean expression intensity of PTH was positively correlated with the number of blood vessels in the adenoma group (R=0.802, p<0.05).
Conclusion:
Normal parathyroid tissue exhibits significantly higher expression levels of PTH and VEGF-A, along with more blood vessels per unit area, compared with adenomatous tissue.
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